{"ATC Code":"N - Nervous system","Abbreviation":["GABA"],"Aliases":["GABA","Piperidic acid","Piperidinic acid","Aminalon","butanoic acid, 4-amino-","Gaballon","γlon","γlone","γsol","Mielomade","Gamarex","γr","Butyric acid, 4-amino-","γ-amino-n-butyric acid","γ-Aminobutanoic acid","Immu-G","γgee","Gamulin","4-aminobutyrate","omega-Aminobutyric acid","Aminalone","4-aminobutanoate","γ-Aminobuttersaeure","γ Aminobutyric acid","Factor I"],"CAS":"56-12-2","ChEBI":"CHEBI:16865","ChEMBL":"CHEMBL96","ChemicalClasses":["gabapentinoid"],"Chirality":"achiral","EINECS":"200-258-6","Esters":[],"Formating":["gamma-aminobutyric acid"],"HMDB ID":"HMDB0000112","Health Effects":"Chronically high levels of GABA are associated with at least 5 inborn errors of metabolism including: D-2-Hydroxyglutaric Aciduria, 4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency, GABA-Transaminase Deficiency, Homocarnosinosis and Succinic semialdehyde dehydrogenase deficiency.","HeavyAtomCount":7,"IUPACName":"4-aminobutanoic acid","InChI":"InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)","InChIKey":"BTCSSZJGUNDROE-UHFFFAOYSA-N","LD50":[{"dosages":[{"amount":"5400 mg/kg","route":"intraperitoneal"},{"amount":"\u0026gt;5 gm/kg","route":"intravenous"}],"organism":"Rat"},{"dosages":[{"amount":"9210 mg/kg","route":"subcutaneous"},{"amount":"2748 mg/kg","route":"intravenous"},{"amount":"4950 mg/kg","route":"intraperitoneal"},{"amount":"12680 mg/kg","route":"oral"}],"organism":"Mouse"},{"dosages":[{"amount":"5 gm/kg","route":"intravenous"}],"organism":"Cat"}],"LDLo":[{"dosages":[{"amount":"18 mg/kg","route":"intracrebral"}],"organism":"Rat"},{"dosages":[{"amount":"2400 mg/kg","route":"intravenous"}],"organism":"Rabbit"}],"MeSH Pharmacological Classification":"Substances used for their pharmacological actions on GABAergic systems. GABAergic agents include agonists, antagonists, degradation or uptake inhibitors, depleters, precursors, and modulators of receptor function.","Melting Point":"203 °C","MolecularFormula":"C\u003csub\u003e4\u003c/sub\u003eH\u003csub\u003e9\u003c/sub\u003eNO\u003csub\u003e2\u003c/sub\u003e","MolecularWeight":"103.12 g/mol","Physical Description":"Solid","PubChemId":119,"RefCount":3,"RefCur":"","References":[{"Name":"Wikipedia","Urls":[{"Link":"https://en.wikipedia.org/wiki/Γ-aminobutyric acid","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"Wikidata","Urls":[{"Link":"https://www.wikidata.org/wiki/Q106345483","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"DrugBank","Urls":[{"Link":"https://go.drugbank.com/drugs/DB02530","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"PubChem","Urls":[{"Link":"https://pubchem.ncbi.nlm.nih.gov/compound/119","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"ChEMBL","Urls":[{"Link":"https://www.ebi.ac.uk/chembl/explore/compound/CHEMBL96","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"ChEBI","Urls":[{"Link":"https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:16865","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"Common Chemistry","Urls":[{"Link":"https://commonchemistry.cas.org/detail?cas_rn=56-12-2","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"HMDB","Urls":[{"Link":"https://hmdb.ca/metabolites/HMDB0000112","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"KEGG","Urls":[{"Link":"https://www.kegg.jp/entry/C00334","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"UNII","Urls":[{"Link":"https://gsrs.ncats.nih.gov/ginas/app/ui/substances/2ACZ6IPC6I","Name":"γ-Aminobutyric acid","Sub":false}]},{"Name":"EPA DSSTox","Urls":[{"Link":"https://comptox.epa.gov/dashboard/chemical/details/DTXSID6035106","Name":"γ-Aminobutyric acid","Sub":false}]}],"Refs":["National Center for Biotechnology Information. PubChem Compound Summary for CID 119, γ-Aminobutyric acid. Accessed September 16, 2025. \u003ca href=https://pubchem.ncbi.nlm.nih.gov/compound/119\u003ehttps://pubchem.ncbi.nlm.nih.gov/compound/119\u003c/a\u003e","U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. γ-Aminobutyric acid. UNII: 2ACZ6IPC6I. Global Substance Registration System. Accessed September 16, 2025. \u003ca href=https://gsrs.ncats.nih.gov/ginas/app/beta/substances/2ACZ6IPC6I\u003ehttps://gsrs.ncats.nih.gov/ginas/app/beta/substances/2ACZ6IPC6I\u003c/a\u003e"],"SMILES":"C(CC(=O)O)CN","SaltData":[{"AcidCount":1,"Amine":"γ-Aminobutyric acid","AmineCount":1,"Formula":"Cl","Name":"hydrochloride","Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 105.337 29.022\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h106v30H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m46.72 18.321-13.198 7.62M33.522 25.941l-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M19.104 19.025V7.002M21.543 19.025V7.002\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M19.104 7.002v6.011M21.543 7.002v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.324 18.321-9.92 5.727M46.72 18.321l13.198 7.62M59.918 25.941l10.045-5.799\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M22.583 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.757-.887-.244-.572-.244-1.334 0-.75.244-1.309.251-.566.757-.881T20.339.56q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.393.523-.393 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.385 25.938q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 28.391h-.62v-2.286H1.173v2.286H.56v-4.9h.613v2.072h2.512v-2.072h.62z\"/\u003e\u003c/g\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M75.057 20.771h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.055h.029l-.017-.328-.024-.476q-.006-.262-.006-.482v-2.769h.577zM79.363 20.771h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619zM81.868 22.26h-1.943v-.3l.772-.778q.221-.222.371-.393.154-.175.232-.34.079-.167.079-.364 0-.243-.147-.368-.142-.128-.371-.128-.214 0-.379.075-.16.075-.328.207l-.193-.243q.171-.147.393-.247.225-.1.507-.1.411 0 .65.208.239.207.239.575 0 .228-.096.432-.093.2-.264.396-.168.197-.393.418l-.615.604v.018h1.486z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m10.404 24.048 4.96-2.864M10.404 24.048l4.96-2.864\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m69.963 20.142-5.022 2.899\" class=\"hi\"/\u003e\u003c/g\u003e\u003cg class=\"mol\"\u003e\u003cg fill=\"#1ff01f\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M102.02 12.66q-.786 0-1.238.53-.453.523-.453 1.446 0 .911.417 1.447.423.53 1.268.53.321 0 .607-.054.292-.06.566-.143v.536q-.274.101-.566.149-.291.053-.696.053-.744 0-1.25-.309-.501-.31-.751-.875-.25-.572-.25-1.34 0-.744.268-1.309.274-.566.804-.882.53-.321 1.28-.321.78 0 1.351.286l-.244.524q-.226-.102-.506-.185-.274-.083-.607-.083m2.757 4.423h-.602v-5.215h.602zM99.113 17.083h-.619v-2.286h-2.513v2.286h-.613v-4.9h.613v2.072h2.513v-2.072h.619z\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"γ-Aminobutyric acid hydrochloride","UNII":"0S3LEB8Q58"}],"Salts":["hydrochloride"],"Solubility":"1.2 [ug/mL] (The mean of the results at pH 7.4)","StereoisomerData":[],"Stereoisomers":[],"Structure":"\u003csvg xmlns=\"http://www.w3.org/2000/svg\" preserveAspectRatio=\"none\" style=\"display:block\" viewBox=\"0 0 82.428 29.022\"\u003e\u003crect width=\"100%\" height=\"100%\" fill=\"#fff\"/\u003e\u003cdesc\u003eGenerated by the Chemistry Development Kit (http://github.com/cdk)\u003c/desc\u003e\u003cg fill=\"#ff0d0d\" stroke=\"#000\" stroke-linecap=\"round\" stroke-linejoin=\"round\" stroke-width=\".7\"\u003e\u003cpath fill=\"#fff\" stroke=\"none\" d=\"M0 0h83v30H0z\"/\u003e\u003cg class=\"mol\"\u003e\u003cpath d=\"m46.72 18.321-13.198 7.62M33.522 25.941l-13.198-7.62\" class=\"bond\"/\u003e\u003cg class=\"bond\"\u003e\u003cpath d=\"M19.104 19.025V7.002M21.543 19.025V7.002\"/\u003e\u003cpath stroke=\"#ff0d0d\" d=\"M19.104 7.002v6.011M21.543 7.002v6.011\" class=\"hi\"/\u003e\u003c/g\u003e\u003cpath d=\"m20.324 18.321-9.92 5.727M46.72 18.321l13.198 7.62M59.918 25.941l10.045-5.799\" class=\"bond\"/\u003e\u003cpath stroke=\"none\" d=\"M22.583 3.078q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.244.315-.756 0-1.262-.315-.506-.316-.757-.887-.244-.572-.244-1.334 0-.75.244-1.309.251-.566.757-.881T20.339.56q.732 0 1.232.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.221.53.839 0 1.22-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.208-.524-.834 0-1.227.524-.393.523-.393 1.452\" class=\"atom\"/\u003e\u003cg stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M9.385 25.938q0 .756-.256 1.328-.256.565-.756.881-.5.315-1.245.315-.756 0-1.262-.315-.506-.316-.756-.887-.244-.572-.244-1.334 0-.75.244-1.309.25-.566.756-.881t1.274-.316q.733 0 1.233.316.5.309.756.875.256.565.256 1.327m-3.864 0q0 .923.387 1.459.393.53 1.22.53.84 0 1.221-.53.387-.536.387-1.459 0-.929-.387-1.452-.381-.524-1.209-.524-.833 0-1.226.524-.393.523-.393 1.452M4.305 28.391h-.62v-2.286H1.173v2.286H.56v-4.9h.613v2.072h2.512v-2.072h.62z\"/\u003e\u003c/g\u003e\u003cg fill=\"#3050f8\" stroke=\"none\" class=\"atom\"\u003e\u003cpath d=\"M75.057 20.771h-.72l-2.619-4.066h-.03l.03.595q.023.357.023.732v2.739h-.565v-4.9h.714l2.608 4.055h.029l-.017-.328-.024-.476q-.006-.262-.006-.482v-2.769h.577zM79.363 20.771h-.619v-2.286h-2.512v2.286h-.613v-4.9h.613v2.072h2.512v-2.072h.619zM81.868 22.26h-1.943v-.3l.772-.778q.221-.222.371-.393.154-.175.232-.34.079-.167.079-.364 0-.243-.147-.368-.142-.128-.371-.128-.214 0-.379.075-.16.075-.328.207l-.193-.243q.171-.147.393-.247.225-.1.507-.1.411 0 .65.208.239.207.239.575 0 .228-.096.432-.093.2-.264.396-.168.197-.393.418l-.615.604v.018h1.486z\"/\u003e\u003c/g\u003e\u003cpath stroke=\"#ff0d0d\" d=\"m10.404 24.048 4.96-2.864M10.404 24.048l4.96-2.864\" class=\"hi\"/\u003e\u003cpath stroke=\"#3050f8\" d=\"m69.963 20.142-5.022 2.899\" class=\"hi\"/\u003e\u003c/g\u003e\u003c/g\u003e\u003c/svg\u003e","Title":"γ-Aminobutyric acid","UNII":"2ACZ6IPC6I","Wikidata":"Q106345483","Wikipedia":"Γ-aminobutyric acid","XLogP":-3.2}